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《医学前沿(英文)》 2023年 第17卷 第3期 页码 527-533 doi: 10.1007/s11684-022-0967-5
关键词: orthotopic heart transplant tricuspid regurgitation clinical impact biatrial heart transplantation
Methodologies for the establishment of an orthotopic transplantation model of ovarian cancer in mice
null
《医学前沿(英文)》 2014年 第8卷 第1期 页码 101-105 doi: 10.1007/s11684-014-0315-5
This study used different methods to establish an animal model of orthotopic transplantation for ovarian cancer to provide an accurate simulation of the mechanism by which tumor occurs and develops in the human body. We implanted 4T1 breast cancer cells stably-transfected with luciferase into BALB/c mice by using three types of orthotopic transplantation methodologies: (1) cultured cells were directly injected into the mouse ovary; (2) cell suspension was initially implanted under the skin of the mouse neck; after tumor mass formed, the tumor was removed and ground into cell suspension, which was then injected into the mouse ovary; and (3) a subcutaneous tumor mass was first generated, removed, and cut into small pieces, which were directly implanted into the mouse ovary. After these models were established, in vivo luminescence imaging was performed. Results and data were compared among groups. Orthotopic transplantation model established with subcutaneous tumor piece implantation showed a better simulation of tumor development and invasion in mice. This model also displayed negligible response to artificial factors. This study successfully established an orthotopic transplantation model of ovarian cancer with high rates of tumor formation and metastasis by using subcutaneous tumor pieces. This study also provided a methodological basis for future establishment of an animal model of ovarian cancer in humans.
SHU Ming, PENG Chenghong, CHEN Hao, SHEN Boyong, ZHOU Guangwen, SHEN Chuan, LI Hongwei
《医学前沿(英文)》 2007年 第1卷 第2期 页码 167-172 doi: 10.1007/s11684-007-0031-5
《医学前沿(英文)》 2022年 第16卷 第2期 页码 295-305 doi: 10.1007/s11684-021-0857-2
关键词: chronic heart failure trimethylamine-N-oxide flavin monooxygenase 3 single nucleotide polymorphism
A literature review of perishable medical resource management
《工程管理前沿(英文)》 页码 710-726 doi: 10.1007/s42524-023-0278-9
关键词: perishable medical resources organ transplant healthcare products decision analytics operations management
Ripen NSENGA MD, Longxian CHENG PhD, Mei’an HE PhD, Tangchun WU PhD,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 437-442 doi: 10.1007/s11684-009-0074-x
关键词: natriuretic peptide precursor A coronary heart disease gene polymorphism allelic discrimination polymorphism single nucleotide
Applications of traditional pump design theory to artificial heart and CFD simulation
WANG Yingpeng, SONG Xinwei, YING Chuntong
《能源前沿(英文)》 2008年 第2卷 第4期 页码 504-507 doi: 10.1007/s11708-008-0059-5
关键词: computational high-efficiency artificial iterative approach artificial traditional
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《医学前沿(英文)》 2013年 第7卷 第3期 页码 301-305 doi: 10.1007/s11684-013-0283-1
Systemic inflammatory response following myocardial ischemia-reperfusion injury (IRI) to a specific organ may cause injuries. Ischemic post-conditioning (IPostC) has emerged as a promising method for myocardial protection against IRI both in experimental and in clinical settings. Enhancement of endogenous nitric oxide (NO) is one of the major mechanisms by which IPostC confers cardioprotection. However, the sensitivity of the diabetic heart to IPostC is impaired and the underlying mechanism is unknown. Adiponectin (APN) is an adipocyte-derived plasma protein with anti-diabetic and anti-inflammatory properties. Plasma levels of APN are decreased in obese subjects and in patients with type 2 diabetes. APN supplementation has been shown to increase NO production and attenuate myocardial IRI in normal (non-diabetic) animals. However, the effect of APN on myocardial injury in diabetic subjects, especially its potential in restoring the sensitivity of the diabetic heart to IPostC has not been investigated. In the current paper, we discussed the possible reasons why the myocardium of diabetic subjects loses sensitivity to IPostC and also highlighted the potential effectiveness and mechanism of APN in restoring IPostC cardioprotection in diabetes. This review proposes to conduct studies that may facilitate the development of novel and optimal therapies to enhance cardioprotection in patients with severe diseases such as diabetes.
关键词: adiponectin ischemic post-conditioning ischemia reperfusion injury diabetes
Hui Wang, Yang Zhang, Zhujun Shen, Ligang Fang, Zhenyu Liu, Shuyang Zhang
《医学前沿(英文)》 2021年 第15卷 第1期 页码 70-78 doi: 10.1007/s11684-020-0749-x
关键词: myocardial infarction percutaneous coronary intervention diabetes mellitus fasting glucose heart failure
ZHANG Kangkang, GU Enhua, LU Junjie
《医学前沿(英文)》 2008年 第2卷 第3期 页码 295-297 doi: 10.1007/s11684-008-0056-4
Current progress on scaffolds of tissue engineering heart valves
DONG Nianguo, SHI Jiawei, CHEN Si, HONG Hao, HU Ping
《医学前沿(英文)》 2008年 第2卷 第3期 页码 229-234 doi: 10.1007/s11684-008-0043-9
Cluster analysis for syndromes of real-world coronary heart disease with angina pectoris
Yufeng Zhao, Xueyun Yu, Xinyu Cao, Lin Luo, Liyun He, Shusong Mao, Li Ma, Peijing Rong, Yuxue Zhao, Guozheng Li, Baoyan Liu
《医学前沿(英文)》 2018年 第12卷 第5期 页码 566-571 doi: 10.1007/s11684-017-0556-1
Syndromes of coronary heart disease with angina pectoris were analyzed to provide guidance for clinical practice and to improve accuracy of traditional Chinese medicine (TCM) diagnoses and efficacy of TCM treatment. A total of 860 cases with coronary heart disease with angina pectoris were selected from TCM Clinical Research Information Sharing System for TCM clinics and research. Syndromes were automatically extracted with the cluster method and were analyzed to provide objective evidence for clinical studies. Final syndrome classifications were recognized and confirmed by clinical experts. Popular syndromes included Qi and blood deficiency, blood stasis and obstruction collaterals, liver depression and spleen deficiency, and Qi stagnation and blood stasis. Syndromes Qi and blood deficiency and blood stasis and obstruction collaterals accounted for 28.61% of total syndromes, whereas liver depression and spleen deficiency and Qi stagnation and blood stasis accounted for 26.44%. The main syndrome elements comprised Qi deficiency, blood deficiency, blood stasis, and Qi stagnation.
关键词: syndrome differentiation real-world study coronary heart disease with angina pectoris cluster analysis
XIA Dasheng, SONG Yanqiu, LI Chao, ZHANG Feng, WEI Minxin
《医学前沿(英文)》 2007年 第1卷 第4期 页码 352-355 doi: 10.1007/s11684-007-0067-6
免疫细胞在器官移植免疫排斥和免疫耐受中的不同作用 Review
干晓杰, 古鉴, 鞠峥, 吕凌
《工程(英文)》 2022年 第10卷 第3期 页码 44-56 doi: 10.1016/j.eng.2021.03.029
器官移植免疫排斥反应是由多种细胞参与的复杂的免疫应答过程,是决定移植成败和患者生存的关键因素。目前大多数器官移植患者采用免疫抑制剂和生物制剂的组合疗法来控制移植器官的免疫排斥反应,然而免疫抑制剂的使用会降低移植患者免疫系统功能,导致严重的并发症,如慢性感染、恶性肿瘤等。因
此,彻底了解器官移植免疫耐受和免疫排斥的相关机制对于开发更好的治疗方案和改善患者预后至关重要。本文对免疫细胞在器官移植免疫排斥和免疫耐受诱导过程中的作用,以及目前针对移植患者处于临床试验阶段的新型细胞治疗进行概述。
Jing Ma, Shiyu Chen, Lili Hao, Wei Sheng, Weicheng Chen, Xiaojing Ma, Bowen Zhang, Duan Ma, Guoying Huang
《医学前沿(英文)》 2021年 第15卷 第1期 页码 91-100 doi: 10.1007/s11684-020-0778-5
关键词: congenital heart disease Gene Expression Omnibus lncRNA SAP30-2:1 cell proliferation RNA immunoprecipitation HAND2
标题 作者 时间 类型 操作
The clinical impact of tricuspid regurgitation in patients with a biatrial orthotopic heart transplant
期刊论文
Methodologies for the establishment of an orthotopic transplantation model of ovarian cancer in mice
null
期刊论文
Intra-abdominal hypertension is an independent cause of acute renal failure after orthotopic liver transplantation
SHU Ming, PENG Chenghong, CHEN Hao, SHEN Boyong, ZHOU Guangwen, SHEN Chuan, LI Hongwei
期刊论文
FMO3--TMAO axis modulates the clinical outcome in chronic heart-failure patients with reduced ejection
期刊论文
The role of natriuretic peptide precursor A gene polymorphism in the development of coronary heart disease
Ripen NSENGA MD, Longxian CHENG PhD, Mei’an HE PhD, Tangchun WU PhD,
期刊论文
Applications of traditional pump design theory to artificial heart and CFD simulation
WANG Yingpeng, SONG Xinwei, YING Chuntong
期刊论文
Adiponectin: mechanisms and new therapeutic approaches for restoring diabetic heart sensitivity to ischemic
null
期刊论文
Prognostic value of fasting glucose on the risk of heart failure and left ventricular systolic dysfunction
Hui Wang, Yang Zhang, Zhujun Shen, Ligang Fang, Zhenyu Liu, Shuyang Zhang
期刊论文
Setting up a heart rate alarm limit to decrease oculocardiac reflex during strabismus surgery in children
ZHANG Kangkang, GU Enhua, LU Junjie
期刊论文
Current progress on scaffolds of tissue engineering heart valves
DONG Nianguo, SHI Jiawei, CHEN Si, HONG Hao, HU Ping
期刊论文
Cluster analysis for syndromes of real-world coronary heart disease with angina pectoris
Yufeng Zhao, Xueyun Yu, Xinyu Cao, Lin Luo, Liyun He, Shusong Mao, Li Ma, Peijing Rong, Yuxue Zhao, Guozheng Li, Baoyan Liu
期刊论文
serum leptin and its relationship with platelet membrane glycoprotein Ib in patients with coronary heart
XIA Dasheng, SONG Yanqiu, LI Chao, ZHANG Feng, WEI Minxin
期刊论文